Optimal experimental designs for dose–response studies with continuous endpoints
نویسندگان
چکیده
منابع مشابه
Optimal designs for trials with discrete time survival endpoints
In studies on event occurrence the main question is whether and when a certain event occurs. Examples of events are smoking initiation, premature termination of therapy and recovery from some disease. The timing of such events cannot always be measured very precisely and coarse time intervals are used instead. At the end of each interval the occurrence of the event is measured, until and includ...
متن کاملMulti-objective optimal experimental designs for event-related fMRI studies
In this article, we propose an efficient approach to find optimal experimental designs for event-related functional magnetic resonance imaging (ER-fMRI). We consider multiple objectives, including estimating the hemodynamic response function (HRF), detecting activation, circumventing psychological confounds and fulfilling customized requirements. Taking into account these goals, we formulate a ...
متن کاملOptimal multistage designs for randomised clinical trials with continuous outcomes
Multistage designs allow considerable reductions in the expected sample size of a trial. When stopping for futility or efficacy is allowed at each stage, the expected sample size under different possible true treatment effects (δ) is of interest. The δ-minimax design is the one for which the maximum expected sample size is minimised amongst all designs that meet the types I and II error constra...
متن کاملInterior Point Methods for Optimal Experimental Designs
In this paper, we propose a primal IP method for solving the optimal experimental design problem with a large class of smooth convex optimality criteria, including A-, Dand pth mean criterion, and establish its global convergence. We also show that the Newton direction can be computed efficiently when the size of the moment matrix is small relative to the sample size. We compare our IP method w...
متن کاملOptimal designs for dose finding studies
Identifying the “right” dose is one of the most critical and difficult steps in the clinical development process of any medicinal drug. Its importance cannot be understated: selecting too high a dose can result in unacceptable toxicity and associated safety problems, while choosing too low a dose leads to smaller chances of showing sufficient efficacy in confirmatory trials, thus reducing the c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Archives of Toxicology
سال: 2014
ISSN: 0340-5761,1432-0738
DOI: 10.1007/s00204-014-1335-2